|
T24430 |
MAO-B Inhibitor 58
|
MAO-B Inhibitor-58 |
|
|
MAO-B inhibitor 58 is an effective, selective, and reversible inhibitor of monoamine oxidase B. |
|
T8849 |
PF-9601N
|
|
MAO
|
|
PF-9601N showed high potency and selectivity as a MAO-BI (monoamine oxidase type B inhibitor) and also demonstrated remarkable neuroprotective properties in several in vivo and cellular models of PD. |
|
T22605 |
Bifemelane hydrochloride
|
|
MAO
,
Monoamine Oxidase
|
|
Bifemelane hydrochloride is a MAO inhibitor |
|
T7626 |
Budipine
|
|
Others
|
|
Budipine is a low affinity, N-methyl-D-aspartate receptor antagonist,is an antiparkinsonian agent. |
|
T18918 |
Azure B
|
Azure B chloride |
MAO
,
Monoamine Oxidase
|
|
Azure B (Azure B chloride) is a cationic dye and the major metabolite of Methylene blue. Azure B is a selective, and reversible inhibitor of MAO-A (IC50s: 11 and 968 nM for recombinant human MAO-A and MAO-B). |
|
T6073 |
OG-L002
|
|
Histone Demethylase
,
Monoamine Oxidase
,
HSV
|
|
OG-L002 is an effective and selective LSD1 inhibitor (IC50: 20 nM), showing 69- and 36-fold selectivity over MAO-A and MAO-B, respectively. |
|
T0300 |
Pargyline
|
Pargylamine,Paragyline |
MAO
,
Monoamine Oxidase
|
|
Pargyline (Pargylamine) is a monoamine oxidase inhibitor with antihypertensive properties. |
|
T1578 |
Pargyline hydrochloride
|
Pargylamine hydrochloride |
MAO
,
Monoamine Oxidase
|
|
Pargyline hydrochloride (Pargylamine hydrochloride) is an irreversible monoamine oxidase(MAO) inhibitor with antihypertensive properties. |
|
T1993 |
J-147
|
J147 |
Epigenetic Reader Domain
,
Dopamine Receptor
,
Monoamine Oxidase
|
|
J-147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging. It is a curcumin derivative and a potent neurogenic and neuroprotective drug candidate... |
|
T10079 |
MAO-IN-1
|
|
MAO
|
|
MAO-IN-1 is a potent monoamine oxidase B (MAO B) inhibitor (IC50: 20 nM) for the study of neurologically related diseases. |
|
T9759 |
MAO-B-IN-5
|
|
|
|
MAO-B-IN-5 is a potent, selective and orally active MAO-B inhibitor with an IC 50 of 0.204 μM. MAO-B-IN-5 has the research potential in Parkinson's disease (PD) [1]. |
|
T60712 |
MAO-B-IN-17
|
|
MAO
|
|
MAO-B-IN-17 is a selective and potent monoamine oxidase B (MAO-B) inhibitor (IC50: 5.08 μM) for the study of central nervous system disorders like Parkinson's. |
|
T71934 |
Atibeprone
|
|
MAO
|
|
Atibeprone is a MAO-B inhibitor with antidepressant activity for the study of Parkinson's disease. |
|
T9560 |
MAO-B-IN-2
|
|
|
|
MAO-B-IN-2 is a selective and competitive inhibitor of MAO-B and BChE with IC 50 values of 0.51 and 7.00 μM, respectively. MAO-B-IN-2 attenuates H2O2-induced cellular damage via good ROS scavenging property. |
|
T28750 |
Sembragiline
|
RG-1577,EVT-302,RO-4602522,RO4602522,RG1577,EVT302 |
MAO
|
|
Sembragiline (EVT-302) is a selective MAO-B inhibitor for the study of Alzheimer's disease (AD). |
|
T6962 |
Rasagiline Mesylate
|
TVP1012,AGN1135,Azilect |
Apoptosis
,
MAO
,
Autophagy
,
Monoamine Oxidase
|
|
Rasagiline Mesylate (AGN1135) is a novel MAO-B inhibitor, which can treat idiopathic Parkinson's disease. |
|
T5676 |
(Z)-SU4312
|
|
MAO
,
NOS
|
|
(Z)-SU4312 is a inhibitor of MAO-B and NOS(IC50 value of 0.2 μM, 19.0μM,respectively). |
|
T60671 |
MAO-B-IN-9
|
|
Beta Amyloid
,
Serotonin Transporter
,
Monoamine Oxidase
|
|
MAO-B-IN-9 is a monoamine oxidase B MAO-B inhibitor (IC50: 0.18 μM) that crosses the blood-brain barrier with potency, selectivity and time-dependence. MAO-B-IN-9 has neuroprotective effects against Aβ1-42-induced neuron... |
|
T60932 |
MAO-B-IN-8
|
|
MAO
|
|
MAO-B-IN-8 is a highly potent and reversible inhibitor of monoamine oxidase-B (MAO-B), which also exhibits inhibitory effects on the microglial production of neuroinflammatory mediators. This compound is specifically des... |
|
T60891 |
AChE/BChE/MAO-B-IN-1
|
|
MAO
,
AChE
|
|
AChE/BChE/MAO-B-IN-1 is a reversible, non-time-dependent inhibitor of AChE, BChE and MAO-B that crosses the blood-brain barrier and exhibits inhibitory effects on hAChE, hBChE and hMAO-B with IC50s of 7.31, 0.56 and 26.1... |
|
T24680 |
PSB-1491
|
|
MAO
|
|
PSB-1491 is a selective and competitive monoamine oxidase B inhibitor with IC50 of 0.386 nM, >25000-fold selective versus MAO-A. |
|
T68069 |
Femoxetine
|
|
MAO
,
5-HT Receptor
|
|
Femoxetine is a 5-HT inhibitor with antidepressant activity that potentiates morphine-induced anti-injury feelings and inhibits MAO-A and MAO-B required for the production of high exercise capacity in mice. |
|
T17211 |
Vafidemstat
|
ORY-2001 |
Histone Demethylase
,
MAO
|
|
Vafidemstat (ORY-2001) is a selective, orally active lysyl-histone demethylase (LSD1)/MAO-B inhibitor that crosses the blood-brain barrier for the study of neurological diseases. |
|
T24679 |
PSB-1434
|
PSB 1434,PSB1434 |
MAO
|
|
PSB-1434 is a selective and competitive monoamine oxidase B inhibitor. |
|
T2315 |
GSK-LSD1 dihydrochloride
|
GSK-LSD1 (hydrochloride),GSK-LSD1 2HCl |
Histone Demethylase
|
|
GSK-LSD1 dihydrochloride (GSK-LSD1 2HCl) is a specificity irreversible LSD1 inhibitor (IC50: 16 nM). The selectivity of GSK-LSD1 for LSD1 is >1000 fold over other closely related FAD utilizing enzymes (i.e. MAO-A, LSD2, ... |
|
T38034 |
MAO-IN-M30 dihydrochloride
|
M 30 dihydrochloride |
Monoamine Oxidase
|
|
MAO-IN-M30 dihydrochloride (M 30 dihydrochloride) is a potent and brain selective monoamine oxidase (MAO) inhibitor (EC50 values are 37 and 57 nM for MAO-A and MAO-B, respectively). Also an iron chelator with antioxidant... |
|
T50055 |
Milacemide
|
|
MAO
|
|
Milacemide is a glycine prodrug and MAO-B inhibitor. Milacemide has been studied for its effects on human memory and as a potential treatment for the symptoms of Alzheimer's disease. |
|
T5887 |
7-Hydroxy-3,4-dihydro-2(1H)-quinolinone
|
3,4-Dihydro-7-hydroxy-2(1H)-quinolinone |
MAO
,
Monoamine Oxidase
|
|
7-Hydroxy-3,4-dihydro-2(1H)-quinolinone is a weak MAO-A inhibitor(with an IC50 of 183 μM) . |
|
T5678 |
Lazabemide hydrochloride
|
N-(2-Aminoethyl)-5-chlor-2-pyridincarbox |
MAO
,
Monoamine Oxidase
|
|
Lazabemide hydrochloride (N-(2-Aminoethyl)-5-chlor-2-pyridincarbox) is a reversible and selective mao-b inhibitor(Ki：7.9nM). |
|
T32535 |
Ladostigil
|
TV-3326,Ladostigil,TV 3326,TV3326,Ladostigil free base |
Antioxidant
,
MAO
,
AChE
|
|
Ladostigil (Ladostigil free base) is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO) with inhibitory effects on MAO-B and AChE, with IC50 values of 37.1 and 31.8 μM, respecti... |
|
T4410 |
LM10
|
|
Others
|
|
Selective tryptophan 2, 3-dioxygenase (TDO) inhibitor (IC50 values are 0.62 and 2 μM for human and mouse TDO, respectively). Exhibits selectivity for TDO over IDO, MAO-A, MAO-B, and a panel of receptors and transporters.... |
|
T1119 |
Rasagiline
|
AGN1135,TVP1012 |
BCL
,
MAO
,
Monoamine Oxidase
|
|
Rasagiline (AGN1135) is an inhibitor of monamine oxidase used as adjunctive therapy in combination with levodopa and carbidopa in the management of Parkinsons disease. |
|
T21652 |
RN-1 dihydrochloride
|
|
Histone Demethylase
,
MAO
|
|
RN-1 dihydrochloride is an effective and selective irreversible inhibitor of lysine-specific demethylase 1 (LSD1, IC50 = 70 nM). |
|
T11882 |
Pulrodemstat benzenesulfonate
|
LSD1-IN-7 benzenesulfonate,CC-90011 benzenesulfonate |
Histone Demethylase
|
|
Pulrodemstat benzenesulfonate (CC-90011 benzenesulfonate) is a potent and orally active inhibitor of lysine specific demethylase-1 (LSD1) with anticancer activity. |
|
T72018 |
MAO-B ligand-1
|
|
|
|
MAO-B ligand-1 is a selective MAO-B inhibitor. |
|
T26750 |
BBDHQ
|
|
|
|
BBDHQ is a selective inhibitor of MAO-B. |
|
T24465 |
Milacemide HCl
|
Milacemide Hydrochloride salt,SC-45864,Milacemide HCl salt,CP-1552S,Milacemide Hydrochloride |
|
|
Milacemide HCl is an MAO-B inhibitor and glycine prodrug. |
|
T61131 |
MAO-B-IN-11
|
|
|
|
MAO-B-IN-11, also known as Compound 8c, is a highly potent inhibitor of monoamine oxidase B (MAO-B), with an IC50 value of 1.3 μM. Additionally, MAO-B-IN-11 exhibits neuroprotective properties [1]. |
|
T10154 |
MAO-B-IN-1
|
|
Others
|
|
MAO-B-IN-1 is a monoamine oxidase B inhibitor and can be used for the research of neurological diseases. |
|
T70492 |
DOOT-2d
|
|
|
|
DOOT-2d is a selective MAO-B inhibitor. |
|
T70569 |
MD-230254
|
|
|
|
MD-230254 is an inhibitor of MAO-B. |
|
T79761 |
MAO-B-IN-25
|
|
Monoamine Oxidase
|
|
MAO-B-IN-25 (compound 92) is a selective inhibitor of monoamine oxidase B (MAO-B), exhibiting inhibitory half-maximal inhibitory concentrations (IC50) of 240 nM for MAO-B and 0.5 nM for MAO-A [1]. |
|
T60660 |
MAO-B-IN-14
|
|
|
|
MAO-B-IN-14 (Compound 9) is a potent and selective inhibitor of monoamine oxidase-B (MAO-B) with an IC 50 of 0.95 μM and a Ki of 0.55 μM for human MAO-B. |
|
T72791 |
AChE/MAO-B-IN-3
|
|
|
|
AChE/MAO-B-IN-3 is a dual inhibitor targeting both acetylcholinesterase (AChE) and monoamine oxidase B (MAO-B), exhibiting inhibitory concentrations (IC50s) of 0.0257 μM and 0.0456 μM against human AChE and MAO-B, respec... |
|
T12088 |
Mofegiline hydrochloride
|
MDL72974A |
Others
|
|
Mofegiline hydrochloride is a potent and selective enzyme-activated irreversible MAO-B inhibitor. |
|
T61321 |
MAO-B-IN-12
|
|
|
|
MAO-B-IN-12 (Compound 16c) is a highly effective inhibitor of monoamine oxidase B (MAO-B), displaying significant potency with an IC50 value of 1.3 μM. Additionally, MAO-B-IN-12 exhibits notable neuroprotective activity ... |
|
T72892 |
AChE/MAO-IN-1
|
|
|
|
AChE/MAO-IN-1 is a potent inhibitor of human acetylcholinesterase (AChE), monoamine oxidase A (MAO-A), and monoamine oxidase B (MAO-B), demonstrating inhibitory concentrations (IC50) of 0.0248 μM, 0.0409 μM, and 0.1108 μ... |
|
T62152 |
Dual AChE-MAO B-IN-2
|
|
|
|
Dual AChE-MAO B-IN-2 is a potent, dual inhibitor of AChE (IC50: 0.12 μM) and MAO B (IC50: 0.01 μM).Dual AChE-MAO B-IN-2 has potential for Alzheimer's disease studies. |
|
T5470 |
LAZABEMIDE
|
Ro 19-6327 |
MAO
,
Monoamine Oxidase
|
|
Lazabemide (Ro 19-6327) is selective, reversible monoamine oxidase B (MAO-B) inhibitor (IC50 values are 0.03 and > 100 μM for MAO-B and MAO-A respectively). |
|
T28559 |
Ro 16-6491
|
Ro166491,Ro-16-6491 |
|
|
Ro 16-6491 is a selective, reversible, orally-active inhibitor of MAO-B. |
